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Frank Emmrich

Frank Emmrich

University of Leipzig, Germany

Title: Perspectives and new process developments in cell therapy

Biography

Biography: Frank Emmrich

Abstract

About 20 years were needed to implement the invention of monoclonal antibodies with clinical and industrial acceptance for novel therapies, and another 10 years for reaching blockbuster level. Now the time has come to welcome cell therapies at the clinical stage with complex procedures that have been developed throughout the last 10 to 15 years. Dendritic cell vaccines, NK cells and chimeric antigen receptor (CAR) T cells are being explored in various configurations in clinical studies. Connected with these developments are new challenges. Certain regulatory authorities find it difficult to handle processes with mixed categories like cell therapy and gene therapy, or combinations of drugs with medical devices. On the manufacturing site originates a demand of for reduction product costs by drastically reducing manual processing steps and implementing automation. Moreover, a better understanding of mechanisms at the molecular and cellular level may reduce costs and risks of new therapeutic procedures for patients. It is well established that anti-CD4 antibody treatment of helper T cells would induce immunological tolerance when applied in the ongoing phase of an immune response. We studied the mechanism and could further develop the procedure to an applicable technology that allows extracorporeal treatment of T cell containing allotransplants thus reducing treatment risks and product costs significantly. If applied in the field of organ transplantation and transplantation antigens the procedure may be useful for preventing graft rejection of organ transplants or the graft versus host disease (GvHD), the most severe adverse reaction upon allogeneic stem cell transplantation.

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