Department of Engineering Technology, College of Technology, University of Houston, Houston, TX 77204, USA.
Title: Upstream bioprocessing of natural colchicine
Biography: Sivakumar Ganapathy
Plant-based colchicine profoundly benefits human health. Demand for ultra-pure natural colchicine, however, is unlikely to be met through conventional production. A new bioprocessing platform has been established using specialized biorhizomes with comprehensive specific-enzymes that catalyze the construction of biogenic functionalized intermediates that convert to colchicine. Biorhizome is a type of compressed scale leaf-derived rhizome tissue, culturally persuaded in vitro. These asexually produced rootstocks, whose buds develop new lateral shoots and adventitious roots that serve as reproductive and storage organs as well as biofactories, are used to biosynthesize high-value pharmaceuticals and others. Additionally, the sprouting biorhizome carries the same genetic code as its parent plant and is totipotent, and thus can be used to study plant metabolic processes. This presentation will focus on discovery of unique biorhizome platform that have evolved toward total biosynthesis of high-value natural colchicine drug.